Mike there both very good rounds. I have both. If your wanting a round just to put them down, the 22-250 is a very flat and accurate shooter. Price wise, i would lean more to the .223. Ammo is cheap, and very plentiful. If your looking to keep hides, the .223 i feel would be a better fit, it doesnt shoot as fast as the 250, but exit with either on a cat will most likely not be the greatest. Look into the 700 sps .223 with a heavy barrel. Im sure you will not be disappointed.